The 49ers’ situation could grow even more dire if Brock Purdy isn’t ready for Sunday’s must-win matchup against the Buffalo ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

For the second successive day, Brock Purdy was listed as limited in San Francisco 49ers practice with the shoulder injury ...

The San Francisco 49ers didn't have many changes to their Thursday practice participation report. One big difference between ...

Christian McCaffrey is deadly serious about his 9-to-5 job — head coach Kyle Shanahan calls him “a psycho in the best way ...

Christian McCaffrey is averaging a mere 3.5 yards per carry this season since he returned from bilateral Achilles tendonitis. Here's what McCaffrey said ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, ...

There may be some justice for a young Packers fan who was denied an autographed football he won this weekend at a 49ers ...

Wide receiver Chris Conley, linebacker Curtis Robinson and more San Francisco 49ers players shared what they're most grateful ...

San Francisco 49ers star Deebo Samuel had a blunt reaction when asked about his low numbers to begin this season.

Olivia Culpo, former Miss Universe, has launched exclusive 49ers gear with Amazon in time for Cyber Monday. This announcement ...

Christen Harper Goff, Alix Earle, Sarah Jane Ramos and more NFL WAGs share with PEOPLE exclusively how they creatively plan ...