Defeating the Bills on the road will be extremely difficult for the 49ers, but they do have a favorable matchup on defense.

Buffalo Bills head coach Sean McDermott has ruled out tight end Dalton Kincaid for Sunday night's game against the San ...

The Buffalo Bills (9-2) roll on in their 2024 regular season journey with a matchup at home against the San Francisco 49ers ...

The Buffalo Bills have the chance to make team history on "Sunday Night Football" against the San Francisco 49ers.

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

Jordan Love threw two touchdown passes to Jayden Reed and the Green Bay Packers capitalized on a fast start to beat Miami ...

The San Francisco 49ers are making another adjustment to their practice squad offensive line. On Friday the team announced ...

Sunday Night Football” could be buried under snow because the game is in New York’s Orchard Park, a town forecast to pick up ...

Ravens quarterback Lamar Jackson has owned the NFC. But his 23-1 mastery will face a significant test from the Philadelphia ...

Drones will take the air at Highmark Stadium during the Buffalo Bills game on Sunday night against the San Francisco 49ers.

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...