Two of the NFL's best headlined a Week 16 matchup with playoff implications, as Christian McCaffrey and the San Francisco 49ers defeated Jonathan Taylor and the Indianapolis Colts, 48-27, at Lucas Oil ...

Caleb Williams has led the Bears to the playoffs in his second NFL season. Michael Reaves / Getty Images By Jayna Bardahl, Kevin Fishbain and Vic Tafur The Chicago Bears and San Francisco 49ers are ...

The San Francisco 49ers have promoted LB Eric Kendricks to the active roster, placed LB Tatum Bethune on the Injured Reserve List. Signed LB Kyzir White to the practice squad, opened the practice ...

The Indianapolis Colts host the San Francisco 49ers on "Monday Night Football" in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games. The Colts, who are without right ...

The San Francisco 49ers came away with a huge win over the Tennessee Titans on Sunday to improve to 10-4 on the season and further bolster their chances of making the playoffs. But as per usual, when ...

The San Francisco 49ers will look to continue their push for the NFL playoffs when they host the Tennessee Titans on Sunday. San Francisco (9-4) is hot on the tails of the Los Angeles Rams and Seattle ...

The 49ers are 9–4, contending for playoffs, led by Christian McCaffrey’s performance. McCaffrey has 1,655 all-purpose yards, 13 touchdowns, and is now uncertain to play on Sunday. If unavailable, ...

Pretty much everyone around the NFL assumes the San Francisco 49ers will trade quarterback Mac Jones in the offseason. But general manager John Lynch is pumping the brakes on the runaway speculation.

Now that the San Francisco 49ers have hit the bye week, it is a good chance for the rookies to breathe. At this point in the season, they are essentially done being rookies and have played enough ...

Shedeur Sanders is gearing up for his second start with the 3-8 Cleveland Browns when the team hosts the 8-4 San Francisco 49ers this Sunday. Sanders threw one touchdown and one interception in his ...

The San Francisco 49ers will make the trip to the Midwest this afternoon for a matchup with the Cleveland Browns. The 49ers are 8-4 and are in third place in the ultra-competitive NFC West division.

The San Francisco 49ers overcame three Brock Purdy interceptions to beat the Carolina Panthers in a defensive battle on "Monday Night Football." In a game that featured five turnovers, the 49ers found ...