One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Here are the full injury reports for the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup at Highmark ...

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...

The Buffalo Bills have reached the playoffs five years in a row, and they're close to making it six. Carson Field breaks down ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December ...

In last week’s 38-10 blowout loss to the Green Bay Packers, the 49ers’ loss had little to do with the weather at Lambeau ...

The 49ers listed Brock Purdy as a limited participant while Nick Bosa and Trent Williams were among those not practicing ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...