Defeating the Bills on the road will be extremely difficult for the 49ers, but they do have a favorable matchup on defense.

The Buffalo Bills (9-2) roll on in their 2024 regular season journey with a matchup at home against the San Francisco 49ers ...

The Buffalo Bills have the chance to make team history on "Sunday Night Football" against the San Francisco 49ers.

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

Buffalo Bills coach Sean McDermott ruled out Dalton Kincaid from playing against San Francisco on Sunday night, while holding ...

Buffalo Bills rookie wide receiver Keon Coleman has been designated as questionable for his team's Week 13 matchup with the ...

The Bills are seemingly getting healthy heading into the matchup, as linebacker Matt Milano and receiver Keon Coleman both ...

The San Francisco 49ers are making another adjustment to their practice squad offensive line. On Friday the team announced ...

Sunday Night Football” could be buried under snow because the game is in New York’s Orchard Park, a town forecast to pick up ...

Miami Dolphins linebacker Jordyn Brooks didn’t hold anything back about his team's effort after a 30-17 loss at frigid Green ...

Matt Maiocco reveals which five 49ers players must step up in San Francisco's must-win Week 13 game against the Buffalo Bills ...

Ravens quarterback Lamar Jackson has owned the NFC. But his 23-1 mastery will face a significant test from the Philadelphia ...