With kickoff fast approaching, we're looking at three keys for the Philadelphia defense vs. the 49ers offense.

The 49ers are dealing with a rash of injuries, while the Eagles have been inconsistent on offense despite deep talent.

San Francisco 49ers coach Kyle Shanahan detailed his memorable first trip to Philadelphia, when an Eagles fan egged his team ...

And ahead of this exciting matchup, ESPN's Nick Wagoner shared Shanahan's immense respect for Fangio. Ahead of this matchup, ...

The chess match between Eagles defensive coordinator Vic Fangio and 49ers offensive guru Kyle Shanahan takes center stage in ...

The 49ers dealt with injuries to almost every one of their stars and still finished 11-5. Now, they are three wins away from ...

Riddled by injuries and dismissed all season, the 49ers enter Sunday's NFC wild-card game in Philadelphia loose and confident ...

Kyle Shanahan, ahead of the team's meeting with the Eagles, revealed a hilarious story about his history with Eagles fans.

The reigning Super Bowl champs have weathered a lot going into Sunday’s playoff showdown with San Francisco in Philadelphia.

The San Francisco 49ers receive a huge Fred Warner playoff update from an NFL insider as the star linebacker eyes a return.

ESPN NFL insider Adam Schefter shared major news on the San Francisco 49ers making a decision before facing the Philadelphia Eagles.

FOX Sports' Jay Glazer shares a promising injury update on 49ers linebacker Fred Warner as San Francisco begins its NFL ...