Researchers at Scripps Research have redesigned fentanyl at the molecular level, challenging decades-old assumptions about opioid chemistry.

On Dec. 15, 2025, President Donald Trump issued an unprecedented executive order “designating fentanyl as a weapon of mass destruction.” Under federal law, fentanyl is a licit — not an illicit — drug.

The Department of Transportation is launching an effort to add the synthetic opioid fentanyl along with norfentanyl to its drug testing panels. “Fentanyl accounts for a large proportion of overdose ...

U.S agencies and Indian authorities are working together to stop fentanyl before it enters the American market.