Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.

An illustration of antibodies, colored pink and blue, over a white background. Antibodies’ flexible loop structures make them difficult to crack with artificial intelligence. Credit: Ian C.

"Despite significant advances in computational protein design in recent years, designing protein binders from scratch remains challenging," explains the study's first author, Kateryna Maksymenko. "To ...

Most of the activities that go on inside cells—the activities that keep us living, breathing, thinking animals—are handled by proteins. They allow cells to communicate with each other, run a cell’s ...

Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Proteins are biology’s molecular machines. They’re our bodies’ construction workers—making muscle, bone, and brain; regulators—keeping systems in check; and local internet—responsible for the ...

Since its release in 2024, the open-source platform BindCraft, developed at EPFL, has already disrupted the world of protein design. Physical interactions between proteins influence anything from cell ...