The San Francisco 49ers, despite careening toward the abyss of NFL mediocrity, still have a path to the postseason as they enter their Week 13 showdown against the Buffalo Bills. Yet, thanks to the rest of the NFC West's tussle with the .

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

With only a few weeks left on the college football slate, NFL draft season is beginning to hit its stride. Before the San Francisco 49ers meet the Buffalo Bills in Week 13, USA TODAY’s NFL Draft Wire released their latest predictions for the 2025 draft with a new mock draft.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

Discover the greatest RBs in San Francisco 49ers history: from Super Bowl heroes to game-changing performers, find out who made the cut.

Watching NFL games, including Fox broadcasts, is simple with Hulu + Live TV, which includes 90 channels, unlimited DVR storage and access to NFL preseason games, live regular season games and studio shows. The service includes ESPN+ and Disney+ in the subscription.

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an injury to his throwing shoulder that has already

Buffalo Bills linebacker Matt Milano has missed the first 11 games of the 2024 season with a bicep injury. Will he return Sunday against the San Francisco 49ers? Buffalo Bills linebacker Matt Milano has missed the first 11 games of the 2024 season with a bicep injury.