Chemical libraries can be screened for small molecules that affect a variety of cellular processes including signal transduction, the cell cycle, and cellular metabolism. In particular, it may be ...

Scientists at Zhengzhou University and affiliated organizations synthesized and optimized a series of thienopyridine indole derivatives leading to the identification of compound [I] as the lead ...

A multi-institutional research collaboration has revealed that the microtubule network (*1), which plays a vital role in cell construction and polarization (*2), utilizes the phase separation (*3) ...

Top: CAMSAP2-mediated polymerization of reconstituted structures in test tubes as observed via electron microscopy, fluorescence microscopy and total internal reflection fluorescence microscopy, ...

Kinesin proteins eat away at microtubules, shortening them and pulling chromosomes to opposite spindle poles during cell division in most organisms. However, fission yeast lacks these proteins, and ...

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes, and ...

Microtubule-targeting agents impact microtubule dynamics to induce mitotic arrest and tumor cell death. Tubulin is therefore a relevant target for the discovery of new agents acting as tumor ...

Almost all cell types exhibit some form of polarity; cell polarity refers to the spatial differences in shape, structure and function within a cell, which enables the cell to carry out specialized ...

Mitotic cell division, when a cell splits into two identical daughter cells, involves lots of moving parts that must be properly organized for accurate segregation. The main players responsible for ...