In aggressive lymphomas, inflammatory messengers reprogram the "conductors" of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in "Nature Cancer" this ...

Findings show lymphoma reshapes stromal cell signaling, replacing structural chemokines with inflammatory signals, leading to ...

Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections and tumors. For these processes to function properly, immune cells (B cells ...

Tumors, such as melanoma, release nanovesicles called exosomes (gray) that travel and lodge in the lymph nodes. There they corrupt the behavior of lymph cells. The lymphatic vessels (green) branch out ...

Structure of a lymph node showing the typical division into different territories for immune cells: B cells are shown in red, T cells in blue, lymphatic vessels in yellow, and stromal cells in cyan.

If you've been hopping between arms for booster shots, a new study suggests that your lymph nodes remember exactly where you first got jabbed and perform far better when you return to that same arm.

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...