Dressed as a boxer, he then takes a victory lap with his supporters. “Pfizer is fighting for 8 cancer breakthroughs by 2030,” reads text near the end of the spot, which then directs viewers to PfizerForAll.com.

Picking up from where last year's Big Game ad debut left off, Pfizer wants to bring a note of resilience and motivation to those fighting cancer in its Super Bowl 59 spot. In the ad, a young boy gets out of his hospital bed,

Thanks in part to LL Cool J ‘s “Mama Said Knock You Out,” Pfizer’s new Super Bowl commercial will leave viewers feeling hyped about the medical company’s ongoing cancer research — but because of the inspiring message at its center, it’ll also likely leave you in tears.

Pfizer is doubling down on its fight against cancer with a 60-second ad set to air during the first quarter of the game.